Ann Liver Transplant.  2023 Nov;3(2):73-79. 10.52604/alt.23.0020.

Living donor liver transplantation for Wilson disease: A collective review

• Park JI
• Chung YK

• KMID: 2560926
• DOI: http://doi.org/10.52604/alt.23.0020

Abstract

Wilson disease (WD) is a recognized metabolic disorder characterized by abnormal copper accumulation and excretion in the human body. The liver-related symptoms may range from acute liver failure to chronic liver disease. Liver transplantation (LT) is primarily indicated for two conditions of WD as acute liver failure and chronic liver disease. LT offers a crucial lifeline for those with WD, with high success rates for graft and patient survival. Living donor liver transplantation (LDLT) recipients for WD generally exhibit superior survival rates, including graft survival, compared to those undergoing LT for other conditions. However, they are still susceptible to the usual risks associated with LDLT. This study intended to review the LDLT cases for WD with acute liver failure and chronic liver disease in the literature. This review included 12 LDLT studies and case reports from Japan (n=3), Turkey (n=2), India (n=2), China (n=2), Saudi Arabia (n=1), Korea (n=1), and United Arab Emirates (n=1). The findings of this review reinforce the efficacy of LDLT in WD, particularly in instances of acute liver failure, while also acknowledging its effectiveness in chronic liver disease.

Keyword

Wilson disease; Acute liver failure; Copper metabolism; Living donors; Liver transplantation