Korean J Dermatol.  2024 Sep;62(8):455-461.

Efficacy and Safety of High- and Low-Frequency Ultrasound with a Regenerative Serum for Facial Skin Anti-Aging Therapy: A Pilot Study

• Lee WG
• Lee SY
• Shin SH
• Han HS
• Park KY

Abstract

Background
Various treatment methods for facial skin anti-aging remain challenging.
Objective
To evaluate the efficacy and safety of a high/low-frequency ultrasound with a skin conditioning topical serum to improve skin conditions.
Methods
A total of twenty healthy Korean participants aged 30∼65 years were recruited. Each participant was treated by a high/low-frequency ultrasound device (CIELO; Staronic) with a skin conditioning serum twice per week for 4 weeks during nine visits. Photographs of each participant were taken at baseline, before each treatment session, and 4 weeks after the last treatment using an imaging tool (Mark-Vu; PSI PLUS). Two-blinded independent evaluators assessed the results using the Physician Global Aesthetic Improvement Scale (PGAIS). Melanin index (MI) and erythema index (EI) were evaluated using a mexameter. Transepidermal water loss (TEWL) was evaluated using a tewameter. Stratum corneum water content was evaluated using a corneometer. Participant satisfaction and adverse events were observed.
Results
MI, EI, TEWL, and stratum corneum water content significantly improved at the ninth visit. A clinical improvement in the PGAIS was observed in 40% (8/20) of participants, and 75% (15/20) of participants reported a high satisfaction score.
Conclusion
High/low-frequency ultrasound combined with a regenerative serum is a potentially safe and effective option for facial skin anti-aging therapy.

Keyword

Pigmentation; Regeneration; Skin aging; Ultrsound