Ann Pediatr Endocrinol Metab.  2024 Aug;29(4):266-275. 10.6065/apem.2346100.050.

Glycated albumin may have a complementary role to glycated hemoglobin in glucose monitoring in childhood acute leukemia

• Sim SY
• Park SJ
• Yoo JW
• Kim S
• Lee JW
• Chung NG
• Cho B
• Suh BK
• Ahn MB

• KMID: 2559455
• DOI: http://doi.org/10.6065/apem.2346100.050

Abstract

Purpose
Glycated hemoglobin (HbA1c) as a glycemic index may have limited value in pediatric patients with acute leukemia as they often present with anemia and/or pancytopenia. To address this issue, we evaluated the usefulness of glycated albumin (GA) as a glycemic monitoring index in pediatric patients with acute leukemia.
Methods
Medical records of 25 patients with type 2 diabetes mellitus (T2DM), 63 patients with acute leukemia, and 115 healthy children from Seoul St. Mary's Hospital, The Catholic University of Korea, were retrospectively investigated for serum GA, HbA1c, and fasting blood glucose (FBG) levels, along with demographic data.
Results
GA, HbA1c, and FBG levels did not differ between the control and acute leukemia groups. In the T2DM group, positive correlations were observed among GA, HbA1c, and FBG (P<0.01). Although GA level was not associated with the HbA1c level in the control group, GA and HbA1c levels showed a positive correlation in the acute leukemia group (P=0.045). Regression analysis revealed GA and HbA1c levels to be positively correlated in the acute leukemia and T2DM groups even after adjusting for age, sex, and body mass index z-score (P=0.007, P<0.01).
Conclusion
GA may be a useful complementary parameter to HbA1c for glycemic monitoring in pediatric patients with acute leukemia, similar to its use in patients with T2DM.

Keyword

Leukemia; Type 2 diabetes mellitus; Glycated albumin; Glycated hemoglobin; Pediatrics

Figure

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  Fig. 1. Flowchart of study population. MODY, monogenic diabetes; TIDM, type 1 diabetes melliuts; T2DM, type 2 diabetes melliuts.

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  Fig. 2. Correlation between the fasting blood glucose level and the HbA1c and glycated albumin levels in each study group. HbA1c, glycated hemoglobin; T2DM, type 2 diabetes melliuts.

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  Fig. 3. Correlation between the BMI z-score and the glycated albumin, HbA1c, and fasting blood glucose levels in each study group. HbA1c, glycated hemoglobin; T2DM, type 2 diabetes melliuts; BMI, body mass index.

Reference

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