Korean J Helicobacter Up Gastrointest Res.
2024 Sep;24(3):281-285. 10.7704/kjhugr.2024.0036.
Kalimate-Associated Gastric Ulcer
- Affiliations
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- 1Department of Internal Medicine Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea
- 2Department of Pathology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea
- KMID: 2558975
- DOI: http://doi.org/10.7704/kjhugr.2024.0036
Abstract
- Kalimate (calcium polystyrene sulfonate) is a cation-exchange resin commonly used in clinical practice to treat hyperkalemia. However, Kalimate has been demonstrated to also cause serious gastrointestinal injuries, such as colonic necrosis, ulcerations, and perforations, in a subset of patients with chronic renal failure; these cases have been reported with and without the administration of hypertonic sorbitol. These lesions usually occur in the large or small intestine; lesions occurring in the stomach are rarely reported. We present the case of a 62-year-old woman with very large Kalimate-induced gastric ulcers that were mistaken for advanced gastric cancer in patients with chronic renal failure who had been taking Kalimate for the previous 3 months. The patient was successfully treated by discontinuing Kalimate and initiating a proton pump inhibitor.
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