J Bone Metab.
2024 Aug;31(3):182-195. 10.11005/jbm.2024.31.3.182.
Body Composition, Sarcopenia, and Serum Myokines in Acromegaly: A Narrative Review
- Inojosa AC
1,2 - Ribeiro AVH1,2
- Araújo TF1,2
- Xavier ME1,2
- Rêgo D1,2
- Bandeira F1,2
- Affiliations
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- 1Division of Endocrinology, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil
- 2FBandeira Endocrine Institute, Recife, Brazil
- KMID: 2558955
- DOI: http://doi.org/10.11005/jbm.2024.31.3.182
Abstract
- Patients with active acromegaly have a higher percentage of lean body mass, a lower percentage of fat body mass, and an increase in their extracellular water compartment compared to healthy individuals. However, muscle function appears to be compromised in patients with acromegaly, with some experiencing worsened physical performance and sarcopenia. Myokine alterations, insulin resistance, dysregulation of protein metabolism, muscle oxidative stress, neuromuscular junction impairment, and increased ectopic intramuscular fat deposits may play roles in muscle dysfunction in patients with acromegaly.
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