Allergy Asthma Respir Dis.  2024 Jul;12(3):160-164. 10.4168/aard.2024.12.3.160.

Eosinophilic granulomatosis with polyangiitis presenting as an endobronchial nodule and atelectasis: A case report

• Yoo WH
• Lee WJ
• Jo EJ
• Park HK

• KMID: 2558376
• DOI: http://doi.org/10.4168/aard.2024.12.3.160

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, multisystemic, small-to-medium vessel vasculitis characterized by asthma, blood and tissue eosinophilia. Pulmonary manifestations in EGPA are variable; however, endobronchial lesions without parenchymal involvement are rare. Herein, we describe a case of EGPA presenting as atelectasis and endobronchial nodule, which was confirmed by bronchoscopic biopsy. A 43-year-old woman with a history of asthma presented with fever, cough, and sputum. Chest computed tomography scan revealed an endobronchial nodule and total atelectasis in the right middle lobe. Bronchoscopy revealed a whitish nodular lesion blocking the right middle lobe bronchus at the origin of the right middle lobe bronchus. A bronchial mucosal biopsy specimen revealed chronic inflammation with eosinophilic angiitis and luminal eosinophilic abscess admixed with mucus. Clinical presentation and pathological results of bronchoscopic biopsy were consistent with EGPA. All symptoms and chest radiographic findings improved after initiating glucocorticoids.

Keyword

Eosinophilic granulomatosis with polyangiitis; Atelectasis; Vasculitis