World J Mens Health.  2024 Jul;42(3):487-501. 10.5534/wjmh.230118.

Advances in Male Contraception: When Will the Novel Male Contraception be Available?

Affiliations
  • 1Department of Medical and Digital Engineering, Hanyang University, Seoul, Korea
  • 2Institute of Nano Science and Technology, Hanyang University, Seoul, Korea
  • 3Department of Mechanical Engineering, Hanyang University, Seoul, Korea
  • 4Department of Urology, College of Medicine, Hanyang University, Seoul, Korea

Abstract

Many contraceptive methods have been developed over the years due to high demand. However, female contraceptive pills and devices do not work for all females due to health conditions and side effects. Also, the number of males who want to actively participate in family planning is gradually increasing. However, the only contraceptive options currently available to males are condoms and vasectomy. Therefore, many male contraceptive methods, including medication (hormonal and nonhormonal therapy) and mechanical methods, are under development. Reversibility, safety, persistence, degree of invasion, promptness, and the suppression of anti-sperm antibody formation are essential factors in the development of male contraceptive methods. In this paper, male contraceptive methods under development are reviewed according to those essential factors. Furthermore, the timeline for the availability of a new male contraception is discussed.

Keyword

Azoospermia; Contraception; Contraceptive agents; Drug development; Spermatogenesis; Sterilization
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