Obstet Gynecol Sci.  2024 May;67(3):304-313. 10.5468/ogs.23268.

Clinical effectiveness of spindle-view intracytoplasmic sperm injection compared to conventional intracytoplasmic sperm injection in patients with poor ovarian response and previous implantation failure

• Kim S
• Cho M
• Chun S
• Park TW
• Joo JH
• Koo YH
• Lee YC

• KMID: 2555514
• DOI: http://doi.org/10.5468/ogs.23268

Abstract

Objective
This study aimed to determine the clinical advantage of spindle-view intracytoplasmic sperm injection (SVICSI; a novel technology) over conventional intracytoplasmic sperm injection (cICSI) in patients with poor ovarian response (POR) and previous implantation failure.
Methods
The study included 37 patients who underwent SVICSI followed by fresh embryo transfer (FET) at a single fertility clinic from January to December 2022, 58 patients who underwent cICSI followed by FET at the same fertility clinic from January to December 2021 as a control group. All study participants met the Bologna criteria for POR and had at least three or more previous failed embryo transfers.
Results
The number of blastocyst transfers was significantly higher in the SVICSI group than in the cICSI group. A good-quality cleavage embryo rate, blastocyst rate, and good-quality blastocyst rate were also significantly higher in the SVICSI group than in the cICSI group. There were no significant differences in the rates of fertilization, implantation, clinical pregnancy, or clinical abortion between the two groups.
Conclusion
In patients with POR, those who underwent SVICSI appeared to have better embryos than those who underwent cICSI. However, whether SVICSI improved clinical outcomes such as implantation and pregnancy rates cannot be proven.

Keyword

Spindle; ICSI; Embryo; Implantation; Pregnancy

Figure

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  Fig. 1 Spindles in living human metaphase II oocytes imaged by using the inverted method according to the angles of deviation with regard to the position of the polar body. (A) 0 o’clock, (B) 1 o’clock, (C) 2 o’clock, (D) 3 o’clock, (E) 4 o’clock, (F) 5 o’clock, (G) 6 o’clock, and (H) spindle invisible. PB, polar body.

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  Fig. 2 Meiotic spindle distribution according to the angles of deviation based on the position of the polar body. A, 0 o’clock; B, 1 o’clock; C, 2 o’clock; D, 3 o’clock; E, 4 o’clock; F, 5 o’clock; G, 6 o’clock; and H, spindle invisible.

Reference

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