Pediatr Infect Vaccine.
2024 Apr;31(1):130-135. 10.14776/piv.2024.31.e2.
Immune Reconstitution Inflammatory Syndrome-Like Reaction During the Treatment of Pneumocystis jirovecii Pneumonia in an Infant With Severe Combined Immunodeficiency
- Affiliations
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- 1Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, the Republic of Korea
- 2Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, the Republic of Korea
- 3Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, the Republic of Korea
- KMID: 2555434
- DOI: http://doi.org/10.14776/piv.2024.31.e2
Abstract
- The effectiveness of corticosteroids in preventing immune reconstitution inflammatory syndrome in non-human immunodeficiency viruses Pneumocystis carinii pneumonia (PCP) patients, such as severe combined immunodeficiency (SCID) patients, is controversial. We experienced a paradoxical reaction during severe PCP treatment in a SCID infant, which responded well to adjuvant corticosteroids.
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