Clin Ultrasound.  2016 Nov;1(2):92-100. 10.18525/cu.2016.1.2.92.

Usefulness of Ultrasonographic Scoring System in Diagnosis of Alcoholic Cirrhosis

• Moon KM
• Baik SK

• KMID: 2555385
• DOI: http://doi.org/10.18525/cu.2016.1.2.92

Abstract

Background/Aims
To evaluate the usefulness of modified ultrasonographic scoring system (mUSSS) compared to that of liver stiffness measurement (LSM) by transient elastography in diagnosis of mild to moderate cirrhosis.
Methods
One hundred and five patients with only alcoholic liver disease (96 males, 9 females; age, 50.5 ± 10.0 year-old) were enrolled in this prospective study. Considering the convenient use of primary medical doctors, we modified the ultrasonographic scoring system reported previously. The mUSSS is composed of 5 parameters; nodularity of the liver surface and edge, parenchyma echogenicity, presence of right-lobe atrophy, spleen size, and splenic vein diameter. The accuracy of mUSSS and LSM in diagnosis of cirrhosis (Laennec fibrosis stage: F4a-F4c) were conducted.
Results
The area under the receiver operating characteristic (ROC) curves of mUSSS and LSM in diagnosis of mild to severe cirrhosis (F4a-F4c) were 0.822 (95% confidence interval [CI] 0.736-0.907) and 0.733 (95% CI 0.625-0.840), respectively. In case of moderate to severe cirrhosis (F4b-F4c), 0.803 for mUSSS (95% CI 0.717-0.890) and 0.754 for LSM (95% CI 0.656-0.853). On basis of ROC curves, more than 5 of mUSSS had 0.957 for sensitivity, 0.429 for specificity, 0.781 for accuracy, in diagnosis of mild to severe cirrhosis. In case of moderate to severe cirrhosis, more than 6 of mUSSS had 0.807 for sensitivity, 0.708 for specificity, 0.762 for accuracy.
Conclusions
In diagnosing alcoholic cirrhosis, mUSSS may have more comparable efficacy than LSM.

Keyword

간경변증; 초음파; 간탄력도검사; 간 조직검사; Fibrosis; Ultrasonography; Elastography; Biopsy