J Korean Med Sci.  2024 Apr;39(14):e137. 10.3346/jkms.2024.39.e137.

Comparison of the Clinical Outcomes Between Early and Delayed Transplantation After SARS-CoV-2 Infection

• Ra SH
• Kim AR
• Jang HM
• Chang E
• Bae S
• Jung J
• Kim MJ
• Chong YP
• Lee SO
• Choi SH
• Kim YS
• Kim SH

• KMID: 2554588
• DOI: http://doi.org/10.3346/jkms.2024.39.e137

Abstract

Our study analyzed 95 solid organ transplant (SOT) and 78 hematopoietic stem cell transplant (HSCT) recipients with prior coronavirus disease 2019 (COVID-19). Patients who underwent transplantation within 30 days of COVID-19 infection comprised the early group, and those who underwent transplantation post-30 days of COVID-19 infection comprised the delayed group. In the early transplantation group, no patient, whether undergoing SOT and HSCT, experienced COVID-19-associated complications. In the delayed transplantation group, one patient each from SOT and HSCT experienced COVID-19-associated complications. Additionally, among early SOT and HSCT recipients, two and six patients underwent transplantation within seven days of COVID-19 diagnosis, respectively. However, no significant differences were observed in the clinical outcomes of these patients compared to those in other patients. Early transplantation following severe acute respiratory syndrome coronavirus 2 infection can be performed without increased risk of COVID-19-associated complications. Therefore, transplantation needs not be delayed by COVID-19 infection.

Keyword

Solid Organ Transplantation; Hematopoietic Stem Cell Transplantation; SARS-CoV-2 Infection; COVID-19

Figure

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  Fig. 1 Study flow diagram.The month(s) refers to the interval between COVID-19 diagnosis and transplantation.SOT = solid organ transplantation, HSCT = hematopoietic stem cell transplantation, COVID-19 = coronavirus disease 2019.

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