J Oral Med Pain.  2024 Mar;49(1):22-27. 10.14476/jomp.2024.49.1.22.

Mucosa-Associated Lymphoid Tissue Lymphoma of the Labial Minor Salivary Glands: Case Report

• Lee JE
• Han D
• Kim HS
• Lee C
• Park Y
• Kwon JS

• KMID: 2554561
• DOI: http://doi.org/10.14476/jomp.2024.49.1.22

Abstract

A 74-year-old female presented with a complaint of dry mouth, continuous spontaneous burning sensation in the tongue, and asymptomatic submucosal soft tissue mass on both sides of the lower labial mucosa. She refused to undergo total excision of the mass due to concern about the possibility of complications such as nerve damage because of the large size of the mass. As her clinical features and magnetic resonance imaging indicated the possibility of Sjögren’s syndrome, a biopsy of the minor salivary gland of the right lower lip was performed. Consequently, she was diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma. Although the patient had typical signs and symptoms of Sjögren’s syndrome, the histopathological result of MALT lymphoma made it impossible to determine whether the patient had a history of Sjögren’s syndrome. For patients with risk factors for MALT lymphoma, such as Sjögren’s syndrome, a biopsy of the labial minor salivary gland with immunohistochemical staining can be helpful in the diagnosis of not only Sjögren’s syndrome but also MALT lymphoma.

Keyword

B-cell; Immunohistochemistry; Lymphoma; Marginal zone; Salivary gland diseases; Sjögren’s syndrome