J Korean Neurosurg Soc.  2024 Mar;67(2):177-185. 10.3340/jkns.2023.0182.

Monocyte Count and Systemic Immune-Inflammation Index Score as Predictors of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

• Lee Y
• Lim YC

• KMID: 2553123
• DOI: http://doi.org/10.3340/jkns.2023.0182

Abstract

Objective
: Delayed cerebral ischemia (DCI) is a major cause of disability in patients who survive aneurysmal subarachnoid hemorrhage (aSAH). Systemic inflammatory markers, such as peripheral leukocyte count and systemic immune-inflammatory index (SII) score, have been considered predictors of DCI in previous studies. This study aims to investigate which systemic biomarkers are significant predictors of DCI.
Methods
: We conducted a retrospective, observational, single-center study of 170 patients with SAH admitted between May 2018 and March 2022. We analyzed the patients’ clinical and laboratory parameters within 1 hour and 3–4 and 5–7 days after admission. The DCI and non-DCI groups were compared. Variables showing statistical significance in the univariate logistic analysis (p<0.05) were entered into a multivariate regression model.
Results
: Hunt-Hess grade “4–5” at admission, modified Fisher scale grade “3–4” at admission, hydrocephalus, intraventricular hemorrhage, and infection showed statistical significance (p<0.05) on a univariate logistic regression. Lymphocyte and monocyte count at admission, SII scores and C-reactive protein levels on days 3–4, and leukocyte and neutrophil counts on days 5–7 exhibited statistical significance on the univariate logistic regression. Multivariate logistic regression analysis revealed that monocyte count at admission (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.04–2.65; p=0.036) and SII score at days 3–4 (OR, 1.55; 95% CI, 1.02–2.47; p=0.049) were independent predictors of DCI.
Conclusion
: Monocyte count at admission and SII score 3–4 days after rupture are independent predictors of clinical deterioration caused by DCI after aSAH. Peripheral monocytosis may be the primer for the innate immune reaction, and the SII score at days 3–4 can promptly represent the propagated systemic immune reaction toward DCI.

Keyword

Monocytes; Systemic immune-inflammation index score; Delayed cerebral ischemia; Aneurysmal subarachnoid hemorrhage

Figure

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  Fig. 1. Study design with inclusion and exclusion criteria for aSAH patients. aSAH : aneurysmal subarachnoid hemorrhage, AVM : arteriovenous malformation, DCI : delayed cerebral ischemia.

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  Fig. 2. Receiver operating characteristic curves to identify patients with delayed cerebral ischemia. SII : Systemic immune-inflammatory index.

Reference

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