Korean J Transplant.  2023 Nov;37(Suppl 1):S296. 10.4285/ATW2023.F-9085.

Cohort profile: Study of Musculoskeletal Health in Renal Transplant (SMART): a prospective cohort study

• Lee J
• Hong N
• Huh KH
• Rhee Y

• KMID: 2551925
• DOI: http://doi.org/10.4285/ATW2023.F-9085

Abstract

Renal transplant recipients often encounter musculoskeletal challenges such as osteoporosis and sarcopenia, which are linked to prolonged glucocorticoid use, physical inactivity, underlying medical conditions, and hormonal imbalances. Despite the evident impact of these issues on posttransplant outcomes, comprehensive studies investigating musculoskeletal health among renal transplant recipients are lacking. To address this gap, we have initiated the Study of Musculoskeletal Health in Renal Transplant (SMART) cohort. The SMART cohort aims to prospectively assess the longitudinal changes in various aspects of musculoskeletal health following renal transplantation. This involves assessing body composition through computed tomography, dual-energy X-ray absorptiometry, and bioimpedance analysis. Additionally, we will measure bone mineral density and muscle function using hand grip strength, 4-meter gait speed, jump power, and chair rise test. We will also evaluate participants quality of life and biochemical parameters. A total of 401 renal transplant recipient participated in the SMART cohort at baseline from September 2020 to July 2023. Among them, 330 received transplants from living donors, while 71 received transplants from deceased donors. The cohorts average age was 50.5 years, with females comprising 42.6% of the participants. The SMART cohort boasts comprehensive muscle function assessments, quantifiable imaging datasets, and detailed information regarding immunosuppression. This initiative will provide valuable longitudinal data on musculoskeletal health in renal transplant recipients.