Korean J Transplant.  2023 Nov;37(Suppl 1):S145. 10.4285/ATW2023.F-7292.

Experience of liver transplantation in National Scientific Center for Surgery Named after A.N. Syzganov

• Tileuov S
• Doskhanov M
• Baimakhanov B
• Kaniev S
• Serikuly E
• Ismatov A
• Skakbayev A
• Mukazhanov D
• Khajiyeva A

• KMID: 2551765
• DOI: http://doi.org/10.4285/ATW2023.F-7292

Abstract

Background
Liver transplantation (LT) is a radical treatment method for recipients with end-stage liver disease. The first LT in Kazakhstan was performed in December 2011 year. Our hospital has more than 10 years of experience in LT by December 2022. This study shows the results after LT in a leading clinic of Kazakhstan.
Methods
From December 2011 to December 2022, 233 LT were performed at the National Scientific Center of Surgery named after A.N. Syzganov. Twenty-four (10.3%) LT were performed from deceased donor and 169 (72.5%) from a living donor. Pediatric LT from a living donor was performed in 40 cases (17.1%). The next graft types were used: right lobe 155, left lobe 23, posterolateral sector-1, dual-graft-1, left lateral sector 29, whole liver 24. Indications for LT were cirrhosis in the outcome: hepatitis C 27, hepatitis B 18, hepatitis B with delta agent 102, primary biliary cirrhosis 30, primary sclerosing cholangitis 5, cryptogenic cirrhosis 8, alimentary-toxic hepatitis 3, Budd-Chiari 1, myofibroblastic tumor 1, steatohepatitis 2, Wilson-Konovalov 1, biliary atresia 23, secondary biliary cirrhosis 2, autoimmune hepatitis 10. Clinical results were retrospectively analyzed.
Results
The overall 5- and 10-year survival rate after LT were 75% and 72.4% correspondingly. Biliary complications after LT were observed in 32 (13.7%), vascular complications in 10 (4.2%), bleeding in 25 (10.7%), rejection crisis in 12 cases (5.1%).
Conclusions
LT in Kazakhstan and in our hospital is actively developing. The main problem at present is the need to develop organ transplantation from deceased donors.