Korean J Transplant.  2023 Nov;37(Suppl 1):S22. 10.4285/ATW2023.F-5898.

The phase angle before transplantation can predict the status of skeletal muscle mass after kidney transplantation

• Kim HJ
• Seong EY
• Jung HJ
• Song SH

• KMID: 2551596
• DOI: http://doi.org/10.4285/ATW2023.F-5898

Abstract

Background
This study aimed to evaluate the association between phase angle, muscle strength, and muscle mass in patients undergoing kidney transplantation.
Methods
Patients whose pre- and follow-up phase angles were measured after kidney transplantation were enrolled. Phase angle and body composition were measured using a multi-frequency bioimpedance analysis device before transplantation and at 7 and 14 days and 3, 6, and 12 months after transplantation. Muscle strength was evaluated using handgrip strength (HGS). Low HGS was defined as <28 kg in males and <18 kg in females. Low muscle mass was defined as a skeletal muscle mass index of <7.0 kg/m² in males and <5.7 kg/m² in females.
Results
A total of 88 patients, with a mean age of 52.3±10.1 years, were analyzed. The mean phase angle of pretransplantation was 5.0±1.0. Muscle mass decreased from 14 days after transplantation compared with that before transplantation and was lowest at 3 months (P<0.001). Body fat percentage was significantly higher at 6 and 12 months after transplantation than at pretransplantation (P<0.0001). Twelve months after kidney transplantation, the prevalence of low HGS decreased (pretransplantation vs. 12 months posttransplantation: 28.4% vs. 17.0%), and the prevalence of low muscle mass (pretransplantation vs. 12 months posttransplantation: 21.6% vs. 28.4%) increased. The pretransplantation phase angle was significantly associated with low muscle mass at 12 months after kidney transplantation (odds ratio [OR], 0.31; 95% confidence interval [CI], 0.10–0.97; P=0.044). The pretransplantation phase angle was not significantly associated with low HGS (OR, 0.01; 95% CI, 0.0005–1.98; P=0.088) 12 months after kidney transplantation.
Conclusions
Pretransplantation phase angle can predict muscle mass status at 12 months after kidney transplantation.