Korean J Otorhinolaryngol-Head Neck Surg.  2024 Jan;67(1):22-27. 10.3342/kjorl-hns.2022.01130.

The Efficacy of Fibrin Sealant to Reduce Complications After Rhinoplasty: A Meta-Analysis

• Kang JW
• Bang JH
• Son SY
• Lee KH

• KMID: 2551079
• DOI: http://doi.org/10.3342/kjorl-hns.2022.01130

Abstract

Background and Objectives
Fibrin sealant (FS) is widely used to reduce postoperative bleeding. This analysis aimed to assess the efficacy of FS to reduce complications after rhinoplasty. Materials and Method We searched PubMed, Scopus, Embase, the Cochrane Library, and the Web of Science database for articles on FS and rhinoplasty from the inception of publication to December 29, 2021. Post-rhinoplasty complications, such as edema and ecchymosis, were recorded. The final meta-analysis was performed using three studies.
Results
Two subgroups were created based on the FS usage after rhinoplasty. The FS effect on edema reduction was favorable on the postoperative day-1 (standardized mean difference [SMD]=-1.07 [-1.70; -0.45]). In addition, the FS effect on ecchymosis reduction was favorable on the postoperative day-1 postoperative (SMD=-1.33 [-2.15; -0.50]).
Conclusion
Our study shows that FS reduces the early complications of rhinoplasty.

Keyword

Adverse effect; Blood coagulation; Ecchymosis; Fibrin; Meta-analysis; Rhinoplasty