Investig Magn Reson Imaging.  2023 Dec;27(4):196-207. 10.13104/imri.2023.0031.

Glymphatic Magnetic Resonance Imaging: Part I—Methodologies for Evaluation of the Glymphatic System

• Lee H
• Yoo RE
• Choi SH

• KMID: 2550187
• DOI: http://doi.org/10.13104/imri.2023.0031

Abstract

Glymphatic magnetic resonance imaging (MRI) is an advanced technique for visualizing the glymphatic system of the brain. We reviewed recent research findings that utilized glymphatic MRI techniques to elucidate the intricate physiological processes of the glymphatic system. We introduce the significance of assessing the glymphatic system by exploring various MRI methodologies, each possessing unique advantages and limitations. Some of these methodologies involve the use of gadolinium-based contrast agents to map the distribution within the brain, while others do not require the use of contrast agents. These approaches offer distinct insights and constraints, enabling researchers to investigate the glymphatic system using MRI. Eventually, glymphatic MRI methodologies will provide invaluable insights to enhance our understanding of the complex pathophysiology of the brain. These findings are expected to contribute significantly to our knowledge and treatment of brain disorders, particularly neurodegenerative diseases. Glymphatic MRI is a crucial reference for exploring promising research avenues in which MRI techniques can play a pivotal role in comprehending and visualizing the brain’s glymphatic system.

Keyword

Glymphatic system; Contrast media; Magnetic resonance imaging; Diffusion tensor imaging