Nucl Med Mol Imaging.  2023 Dec;57(6):301-305. 10.1007/s13139-023-00806-5.

The ‘Eye Mask Sign’ in Fibrous Dysplasia on  ^99mTc‑MDP Skeletal Scintigraphy and SPECT/CT

• Jain S
• Singh D
• Jain S

• KMID: 2549943
• DOI: http://doi.org/10.1007/s13139-023-00806-5

Abstract

Fibrous dysplasia (FD) is a fibro-osseous disorder that manifests with distinct or overlapping clinical patterns. FD may be monostotic or polyostotic and commonly associated with syndromes such as McCune-Albright syndrome and Mazabraud syndrome. We report a case of polyostotic FD with bilateral involvement of craniofacial bones in a distinct pattern and propose this characteristic appearance as the ‘eye mask sign’ on ^99mTc-Methylene Diphosphonate (MDP) skeletal scintigraphy and SPECT/CT. Other unusual skeletal scintigraphic features noted in this case are also described (Figs. 1, 2, and 3).

Keyword

The ‘eye mask’ sign; Fibrous dysplasia; ^99mTc-MDP bone scan; Atypical skull involvement in FD