Immune Netw.
2023 Aug;23(4):e33. 10.4110/in.2023.23.e33.
SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents
- Choi S
1,2 - Kim SH3
- Han MS2,4
- Yoon Y5
- Kim YK6
- Cho HK7
- Yun KW2,8
- Song SH2,8
- Ahn B2,8
- Kim YK2,8
- Choi SH8
- Choe YJ9
- Lim H10
- Choi EB10
- Kim K10
- Hyeon S10
- Lim HJ10
- Kim Bc10
- Lee Yk10
- Choi EH2,8
- Shin EC3,11
- Lee H1,2
- Affiliations
-
- 1Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam 13620, Korea
- 2Department of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea
- 3The Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon 34126, Korea
- 4Department of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul 07061, Korea
- 5Department of Pediatrics, Korea University Guro Hospital, Seoul 08308, Korea
- 6Department of Pediatrics, Korea University College of Medicine, Seoul 02841, Korea
- 7Department of Pediatrics, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Korea
- 8Department of Pediatrics, Seoul National University Children’s Hospital, Seoul 03080, Korea
- 9Department of Pediatrics, Korea University Anam Hospital, Seoul 02841, Korea
- 10Division of Vaccine Development Coordination, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea
- 11Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
- KMID: 2549159
- DOI: http://doi.org/10.4110/in.2023.23.e33
Abstract
- Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccineinduced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARSCoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4+ T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4+ T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.
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