Ann Dermatol.
2023 Dec;35(6):389-399. 10.5021/ad.23.072.
Genetic Studies of Actinic Keratosis Development: Where Are We Now?
- Affiliations
-
- 1Department of Biomedicine & Health Science, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 2Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 3Genomic Medicine Institute (GMI), Medical Research Center, Seoul National University, Seoul, Korea
- 4Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea
- 5Cancer Research Institute, Seoul National University, Seoul, Korea
- 6Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2548827
- DOI: http://doi.org/10.5021/ad.23.072
Abstract
- Actinic keratosis (AK) is a common precancerous skin lesion that can develop into cutaneous squamous cell carcinoma (CSCC). AK is characterized by atypical keratinocytes in the skin’s outer layer and is commonly found in sun-exposed areas. Like many precancerous lesions, the development of AK is closely associated with genetic mutations. The molecular biology and transcriptional mechanisms underlying AK development are not well understood. Ultraviolet (UV) light exposure, especially UVA and UVB radiation, is a significant risk factor for AK, causing DNA damage and mutagenic effects. Besides UV exposure, comorbidities like diabetes, rheumatoid arthritis, and psoriasis may also influence AK development. AK patients have shown associations with various internal malignancies, indicating potential vulnerability in cancer-associated genes. Treatment for AK includes cryosurgery, electrodesiccation and curettage, chemotherapeutic creams, photodynamic therapy, or topical immune-modulators. Genomic studies have identified genetic aberrations in AK, with common mutations found in genes like TP53, NOTCH1, and NOTCH2. The progression from AK to CSCC involves chromosomal aberrations and alterations in oncogenes and tumor-suppressor genes. The functional relationships among these genes are not fully understood, but network analysis provides insights into their potential mechanisms. Further research is needed to enhance our understanding of AK’s pathogenesis and develop novel therapeutic approaches.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Clearance of Actinic Keratosis Caused by the Prodrug of 5-Fluorouracil
- Prevalence of Actinic Keratosis on a Facial Aesthetic Unit
- Basal Cell Carcinoma Arising from the Scar of Laser Ablation for a Pre-Existing Actinic Keratosis
- A Case of Multiple Actinic Keratoses during PUVA Therapy in a Vitiligo patient
- Multiple Actinic Keratoses Induced by Phototherapy in a Korean Psoriatic Patient
