J Korean Acad Pediatr Dent.  2023 Nov;50(4):421-433. 10.5933/JKAPD.2023.50.4.421.

Assessment of Risk Factors for Dental Developmental Disorders in Pediatric Cancer Survivors

• Lee J
• Choi HJ
• Lee J
• Song JS
• Kang CM

• KMID: 2548202
• DOI: http://doi.org/10.5933/JKAPD.2023.50.4.421

Abstract

This study was to examine the developmental dental abnormalities in childhood cancer survivors. Risk factors were assessed for 125 children with radiographic data through a retrospective analysis of medical records and panoramic images. 68.0% of childhood cancer survivors exhibited at least one dental abnormality. The types of abnormalities varied depending on the age at cancer diagnosis and treatment intensity, ranging from microdontia (43.2%), to abnormal root development (39.2%) and tooth agenesis (33.6%). Logistic regression analysis demonstrated that a young age at diagnosis (under 3 years), the use of heavy metal agents, a history of hematopoietic stem cell transplantation (HSCT), and combination treatment of chemotherapy, radiation therapy, and HSCT were associated with a significantly higher risk for overall dental abnormalities. The increased risk ratios were 6.00, 3.06, 3.22, and 7.87, respectively (p < 0.05). The results of this study will predict dental abnormality in permanent dentition according to the diagnosis age and treatment method of childhood cancer.

Keyword

Childhood cancer; Dental abnormality; Tooth agenesis; Microdontia; Abnormal root development