Korean J Intern Med.
2023 Nov;38(6):903-911. 10.3904/kjim.2022.358.
Nailfold capillaroscopy findings of interstitial pneumonia with autoimmune features
- Affiliations
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- 1Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea
- 2Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea
- 3Department of Rheumatology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea
- 4Division of Pulmonary Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
- 5Precision Medicine Lung Cancer Center, Konkuk University Medical Center, Seoul, Korea
- KMID: 2547648
- DOI: http://doi.org/10.3904/kjim.2022.358
Abstract
- Background/Aims
We evaluated nailfold capillaroscopy (NFC) of interstitial pneumonia with autoimmune features (IPAF) and compared it with that of patients with connective tissue disease-interstitial lung disease (CTD-ILD) and idiopathic interstitial pneumonia (IIP).
Methods
Patients with newly diagnosed as ILD were evaluated using NFC. Baseline demographic, clinical, serological, and high-resolution CT findings were collected. NFC was semi-quantitatively scored with six domains ranging from 0 to 18. In addition, the overall patterns (scleroderma/non-scleroderma patterns) were determined.
Results
A total of 81 patients (31 with CTD-ILD, 18 with IPAF, and 32 with IIP) were included. The non-specific interstitial pneumonia pattern was the most common ILD pattern in the CTD-ILD and IPAF groups, whereas the usual interstitial pneumonia pattern was the most common in the IIP group. The semi-quantitative score of the CTD-ILD group was higher than that of the IPAF or IIP groups (5.8 vs 4.2 vs 3.0, p < 0.001, respectively). Giant capillaries and haemorrhages were more frequently present in the CTD-ILD and IPAF groups than in the IIP group. A scleroderma pattern was present in 27.8% of the IPAF group, whereas none of the IIP patients showed a scleroderma pattern.
Conclusions
NFC findings may be useful in classifying patients with ILD into CTD-ILD/IPAF/IIP.
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