Ann Clin Neurophysiol.  2023 Oct;25(2):78-83. 10.14253/acn.2023.25.2.78.

Nociplastic pain

• Cho JH

• KMID: 2547399
• DOI: http://doi.org/10.14253/acn.2023.25.2.78

Abstract

Nociplastic pain refers to pain arising from altered nociception without evidence of tissue or somatosensory damage. It encompasses various clinical conditions with shared neurophysiological mechanisms involving dif ferent organ systems. Nociplastic pain can occur independently or alongside chronic pain conditions with a nociceptive or neuropathic origin. This review introduces the concept of nociplastic pain, its clinical manifestations and the underlying pathophysiology. Taking a biopsychosocial approach can lead to a better understanding of nociplastic pain and improved treatment outcomes for affected individuals.

Reference

1. Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020; 161:1976–1982.

2. International Association for the Study of Pain. IASP terminology [Internet]. Washington (DC): International Association for the Study of Pain;c2023. [accessed 2023 Aug 3]. Available from: https://www.iasp-pain.org/resources/terminology/.

3. Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021; 397:2082–2097.

4. Murphy AE, Minhas D, Clauw DJ, Lee YC. Identifying and managing nociplastic pain in individuals with rheumatic diseases: a narrative review. Arthritis Care Res (Hoboken). 2023; 75:2215–2222.

5. Kosek E, Cohen M, Baron R, Gebhart GF, Mico JA, Rice ASC, et al. Do we need a third mechanistic descriptor for chronic pain states? Pain. 2016; 157:1382–1386.

6. World Health Organization. ICD-11 for mortality and morbidity statistics [Internet]. Geneva: World Health Organization;c2023. [accessed 2023 Aug 3]. Available from: https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1326332835.

7. Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the International Classification of Diseases (ICD-11). Pain. 2019; 160:19–27.

8. Fitzcharles MA, Cohen SP, Clauw DJ, Littlejohn G, Usui C, Häuser W. Nociplastic pain: towards an understanding of prevalent pain conditions. Lancet. 2021; 397:2098–2110.

9. Nicholas M, Vlaeyen JWS, Rief W, Barke A, Aziz Q, Benoliel R, et al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain. 2019; 160:28–37.

10. Kosek E, Clauw D, Nijs J, Baron R, Gilron I, Harris RE, et al. Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system. Pain. 2021; 162:2629–2634.

11. Nijs J, Lahousse A, Kapreli E, Bilika P, Saraçoğlu İ, Malfliet A, et al. Nociplastic pain criteria or recognition of central sensitization? Pain phenotyping in the past, present and future. J Clin Med. 2021; 10:3203.

12. den Boer C, Dries L, Terluin B, van der Wouden JC, Blankenstein AH, van Wilgen CP, et al. Central sensitization in chronic pain and medically unexplained symptom research: a systematic review of definitions, operationalizations and measurement instruments. J Psychosom Res. 2019; 117:32–40.

13. Nijs J, George SZ, Clauw DJ, Fernández-de-las-Peñas C, Kosek E, Ickmans K, et al. Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine. Lancet Rheumatol. 2021; 3:e383–e392.

14. Ramaswamy S, Wodehouse T. Conditioned pain modulation-A comprehensive review. Neurophysiol Clin. 2021; 51:197–208.

15. Ibancos-Losada MDR, Osuna-Pérez MC, Castellote-Caballero MY, Díaz-Fernández Á. Conditioned pain modulation effectiveness: an experimental study comparing test paradigms and analyzing potential predictors in a healthy population. Brain Sci. 2020; 10:599.

16. Neblett R. The central sensitization inventory: a user’s manual. J Appl Biobehav Res. 2018; 23:e12123.