Infect Chemother.
2023 Sep;55(3):403-407. 10.3947/ic.2023.0058.
Norovirus Infection in Children with Acute Lymphoblastic Leukemia
- Affiliations
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- 1Department of Pediatric Hematology and Oncology, KMC Hospital, Ambedkar circle, Mangalore, India
- 2Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India
- KMID: 2546686
- DOI: http://doi.org/10.3947/ic.2023.0058
Abstract
- Norovirus infection in children on treatment for acute lymphoblastic leukemia can lead to severe morbidity due to chronic viral shedding, malabsorption, failure to thrive, and interruption of chemotherapy. We had four children with norovirus diarrhoea in eight years period in our pediatric oncology unit. Three children under two years of age had chronic noroviral shedding and persistent diarrhoea, probably due to poor adaptive immune responses. Two of those children didn’t respond to nitazoxanide and succumbed to the illness. The third patient who received nitazoxanide and favipiravir, is currently well on chemotherapy.
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