J Stroke.  2023 Sep;25(3):409-412. 10.5853/jos.2023.00276.

Digital Therapeutics With Visual Discrimination Training for Cortical Blindness in Patients With Chronic Stroke

Affiliations
  • 1Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 2Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea
  • 3Nunaps Inc., Seoul, Korea
  • 4Asan Institute for Life Sciences, Seoul, Korea
  • 5Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, RI, USA


Figure

  • Figure 1. Study scheme and training protocols. (A) Study scheme. (B) Location of fixation and texture stimuli for training. A response to the fixation stimulus is required in less than 2 seconds, followed by a response to the texture stimulus within 6 seconds. The next trial starts immediately after the response to the texture stimulus. (C) An example composite Humphrey visual field test of a trained stroke patient; the green square indicates the coverage of the texture stimulus for training. (D) The training setting. (E) The trial sequence for training. HVF, Humphrey visual field; ODT, orientation discrimination task; VPL, visual perceptual learning.

  • Figure 2. Outcome variables between the untrained and trained groups. (A) Areas improved (≥6 dB); (B) areas worsened (≥6 dB); (C) changes in mean total deviation (dB) between baseline and 3 months; (D) mean total deviation improved between baseline and 3 months.


Reference

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