Clin Psychopharmacol Neurosci.
2023 Aug;21(3):604-608. 10.9758/cpn.22.1044.
Successful Early Lamotrigine and Aripiprazole Augmentation of Clomipramine in Severe Obsessive-compulsive Disorder
- Affiliations
-
- 1Premedical Science, College of Medicine, Chosun University, Gwangju, Korea
- 2Department of Psychiatry, College of Medicine, Chosun University, Gwangju, Korea
- 3Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
- KMID: 2545820
- DOI: http://doi.org/10.9758/cpn.22.1044
Abstract
- Lamotrigine and aripiprazole have shown efficacy as augmentation agents of serotonin reuptake inhibitors for treatment-resistant obsessive-compulsive disorder (OCD). To date, the efficacy of lamotrigine/aripiprazole augmentation has not been reported in OCD treatment. Herein, we report the case of a 37-year-old male with severe OCD and comorbid depression whose symptoms markedly improved after low-dose lamotrigine/aripiprazole augmentation to clomipramine. Our report suggests that early glutamatergic/antipsychotic augmentation contributes to rapid remission of OCD symptoms.
