Korean J Intern Med.
2023 Sep;38(5):651-660. 10.3904/kjim.2023.030.
Efficacy and safety of 1 L polyethylene glycol plus ascorbic acid for bowel preparation in elderly: comparison with oral sulfate solution
- Lim KY1
- Kim KO
1 - Kim EY2
- Lee YJ3
- Jang BI1
- Kim SK4
- Yang CH5,6
- on behalf of Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)1
- Affiliations
-
- 1Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
- 2Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea
- 3Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
- 4Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
- 5Health Promotion Center, Yeungnam University College of Medicine, Daegu, Korea
- 6Deparment of Internal Medicine, Dongguk University School of Medicine, Gyeongju, Korea
- KMID: 2545690
- DOI: http://doi.org/10.3904/kjim.2023.030
Abstract
- Background/Aims
Recently, 1 L of polyethylene glycol (PEG) plus ascorbic acid (Asc) has been introduced in Korea as a colonoscopy preparation agent. Data on its efficacy and safety in older adults have been limited. We aimed to evaluate the safety and efficacy of 1 L PEG/Asc in older adults by comparing it with oral sulfate solution (OSS).
Methods
A prospective multicenter randomized study was conducted with subjects aged ≥ 65 years who underwent colonoscopy. The participants were randomized to receive 1 L PEG/Asc or OSS. The primary endpoint was successful bowel preparation, defined as total Boston Bowel Preparation Scale ≥ 6, and ≥ 2 at each segment. Patient satisfaction, adverse events, and renal function changes were compared between the groups.
Results
Among the 106 patients, 104 were finally included in the analysis. Overall, successful bowel preparation was achieved in 96.2% of both 1 L PEG/Asc and OSS groups. The satisfaction scores for taste, total amount ingested, overall feeling, and willingness to repeat the same regimen were not significantly different between the groups. Adverse events of moderate or higher severity occurred in 16 and 10 cases in the 1 L PEG/Asc and OSS group, respectively. There were no significant changes in electrolyte levels or renal function from baseline.
Conclusions
The successful bowel preparation rate was > 90% in both groups without severe adverse effects and significant changes in renal function. As a new low-dose preparation regimen for colonoscopy in older adults, 1 L PEG/Asc, is as effective and safe as OSS.
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