Nucl Med Mol Imaging.  2023 Aug;57(4):168-171. 10.1007/s13139-023-00804-7.

¹⁶¹Tb‑PSMA Unleashed: a Promising New Player in the Theranostics of Prostate Cancer

• Al‑Ibraheem A
• Scott A

• KMID: 2545312
• DOI: http://doi.org/10.1007/s13139-023-00804-7

Abstract

Radiotheranostics with ¹⁷⁷Lu-PSMA have changed the treatment paradigm in patients with prostate cancer, becoming the new standard in certain settings. Terbium-161 ( ¹⁶¹Tb) has been recently investigated as a potential radionuclide for radiotheranostics in various types of cancer, including metastatic castration-resistant prostate cancer (mCRPC). The nuclear medicine team at King Hussein Cancer Center (KHCC) in Amman, Jordan, recently published the first-in-human SPECT/ CT imaging results following a well-tolerated dose of ¹⁶¹Tb-PSMA radioligand therapy with no treatment-related adverse events, adding to the potential of radiotheranostics in prostate cancer. Two clinical trials for ¹⁶¹Tb-PSMA radioligand therapy in prostate cancer are currently underway and will provide valuable insights. This review will shed light on the expanding field of radiotheranostics in prostate cancer, which is not without challenges, and will discuss how the introduction of a new therapeutic option like ¹⁶¹Tb-PSMA may help to combat these challenges and build on the proven success of ¹⁷⁷Lu-PSMAbased radiotheranostics for the benefit of prostate cancer patients worldwide.

Keyword

¹⁶¹Tb-PSMA; Radiotheranostics; Nuclear medicine; Prostate cancer; King Hussein Cancer Center (KHCC); Jordan