Tissue Eng Regen Med.  2023 Aug;20(5):661-670. 10.1007/s13770-023-00536-x.

Development of Matrix Metalloproteinases-Mediated Extracellular Matrix Remodeling in Regenerative Medicine: A Mini Review

• Chen K
• Xu M
• Lu F
• He Y

• KMID: 2545045
• DOI: http://doi.org/10.1007/s13770-023-00536-x

Abstract

Extracellular matrix (ECM) components confer biomechanical properties, maintain cell phenotype and mediate tissue homeostasis. ECM remodeling is complex and plays a key role in both physiological and pathological processes. Matrix metalloproteinases (MMPs) are a group of enzymes responsible for ECM degradation and have been accepted as a key regulator in ECM remodeling. In this mini-review, we summarize MMPs categories, functions and the targeted substrates. We then discuss current understanding of the role of MMPs-mediated events, including inflammation reaction, angiogenesis, cellular activities, etc., in ECM remodeling in the context of regenerative medicine.

Keyword

Matrix metalloproteinases; ECM remodeling; Regenerative medicine; Matrikines