J Urol Oncol.  2023 Jul;21(2):140-147. 10.22465/juo.234600180009.

Korean Urologic Oncology Society Guidelines: Does Angioembolization Improve the Quality of Life for Renal Cell Carcinoma Patients With Intractable Symptoms Who Are Unfit for Surgery?

• Ku JY
• Gu HM
• Yu SH
• Hwang EC
• Han MA
• Jung JH
• Lee H
• Kim MH
• Kwak C
• Kim SI
• for the Korean Urologic Oncology Society Guideline Development Committee
• Korean Renal Cancer Study Group

• KMID: 2544864
• DOI: http://doi.org/10.22465/juo.234600180009

Abstract

Purpose
There is a lack of guidelines for using angioembolization to manage renal cell carcinoma (RCC) patients with intractable symptoms. Therefore, the Korean Urologic Oncology Society (KUOS) developed a set of recommendations for angioembolization for RCC patients with intractable symptoms who are unfit for surgery.
Materials and Methods
A rigorous systematic review was performed and GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) methodology was used to rate the certainty of the evidence for the patient outcomes and to develop the evidence into recommendations. The steering group, guidelines development group, systematic review team, and external review group consisted of KUOS members involved in the guideline development process.
Results
The guidelines address the benefits, harms, patients’ values and preferences, costs, and resources related to angioembolization by using a single clinical question: Does angioembolization improve the quality of life for RCC patients with intractable symptoms who are unfit for surgery?
Conclusions
The guideline development panel suggests angioembolization for RCC patients with intractable symptoms compared with supportive therapies, including systemic treatment (very low certainty of evidence, weak recommendation).

Keyword

Renal cell carcinoma; Therapeutic embolization; GRADE approach; Guideline