Ann Surg Treat Res.  2023 Jul;105(1):37-46. 10.4174/astr.2023.105.1.37.

Treatment of abdominal aortic aneurysms in Korea: a nationwide study

Affiliations
  • 1Department of Surgery, Ewha Womans University College of Medicine, Seoul, Korea
  • 2Division of Vascular Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 3Department of Emergency Critical Care Trauma Surgery, Korea University Guro Hospital, Seoul, Korea
  • 4Armed Forces Trauma Center, Seongnam, Korea
  • 5Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Abstract

Purpose
Although endovascular aneurysm repair (EVAR) has been shown to be superior to open surgical repair (OSR) for abdominal aortic aneurysm (AAA) treatment, no large-scale studies in the Korean population have compared outcomes and costs.
Methods
The National Health Insurance Service database in Korea was screened to identify AAA patients treated with EVAR or OSR from 2008 to 2019. Perioperative, early postoperative, and long-term survival were compared, as were reinterventions and complications. Patients were followed-up through 2020.
Results
Of the 13,631 patients identified, 2,935 underwent OSR and 10,696 underwent EVAR. Perioperative mortality rate was lower in the EVAR group (4.2% vs. 8.0%, P < 0.001) even after excluding patients with ruptured AAA (2.7% vs. 3.3%, P = 0.003). However, long-term mortality rate per 100 person-years was significantly higher in the EVAR than in the OSR group (9.0 vs. 6.4, P < 0.001), and all-cause mortality was lower in the OSR group (hazard ratio, 0.9; 95% confidence interval, 0.87–0.97, P = 0.008). EVAR had a higher AAA-related reintervention rate per 100 person-years (1.75 vs. 0.52), and AAA-related reintervention costs were almost 10-fold higher with EVAR (US dollar [USD] 6,153,463) than with OSR (USD 624,216).
Conclusion
While EVAR may have short-term advantages, OSR may provide better long-term outcomes and costeffectiveness for AAA treatment in the Korean population, under the medical expense system in Korea.

Keyword

Abdominal aortic aneurysm; Costs and cost analysis; Endovascular aneurysm repair

Figure

  • Fig. 1 Flow diagram. NHIS, National Health Insurance Service; ICD-10, International Classification of Disease, 10th revision; AAA, abdominal aortic aneurysm.

  • Fig. 2 Annual number of procedures, including endovascular aneurysm repair (EVAR) and open surgical repair (OSR). (A) Total number of procedures; (B) the number of patients aged <60 years and ≥50 years; (C) the number of patients aged ≥60 years who underwent each procedure.

  • Fig. 3 All-cause mortality over time from 2009 to 2018 in (A) all patients, (B) patients with unruptured abdominal aortic aneurysm (AAA), and (C) patients with ruptured AAA. EVAR, endovascular aneurysm repair; OSR, open surgical repair.


Reference

1. Laine MT, Laukontaus SJ, Kantonen I, Venermo M. Population-based study of ruptured abdominal aortic aneurysm. Br J Surg. 2016; 103:1634–1639. PMID: 27508946.
2. Lederle FA, Freischlag JA, Kyriakides TC, Padberg FT Jr, Matsumura JS, Kohler TR, et al. Outcomes following endovascular vs open repair of abdominal aortic aneurysm: a randomized trial. JAMA. 2009; 302:1535–1542. PMID: 19826022.
3. EVAR trial participants. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet. 2005; 365:2179–2186. PMID: 15978925.
4. Patel R, Sweeting MJ, Powell JT, Greenhalgh RM. EVAR trial investigators. Endovascular versus open repair of abdominal aortic aneurysm in 15-years' fol low-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial. Lancet. 2016; 388:2366–2374. PMID: 27743617.
5. George EL, Arya S, Ho VT, Stern JR, Sgroi MD, Chandra V, et al. Trends in annual open abdominal aor t ic surgical volumes for vascular trainees compared with annual national volumes in the endovascular era. J Vasc Surg. 2022; 76:1079–1086. PMID: 35598821.
6. Schermerhorn ML, Buck DB, O'Malley AJ, Curran T, McCallum JC, Darling J, et al. Long-term outcomes of abdominal aortic aneurysm in the medicare population. N Engl J Med. 2015; 373:328–338. PMID: 26200979.
7. Prinssen M, Verhoeven EL, Buth J, Cuypers PW, van Sambeek MR, Balm R, et al. A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms. N Engl J Med. 2004; 351:1607–1618. PMID: 15483279.
8. van Schaik TG, Yeung KK, Verhagen HJ, de Bruin JL, van Sambeek MR, Balm R, et al. Long-term survival and secondary procedures after open or endovascular repair of abdominal aortic aneurysms. J Vasc Surg. 2017; 66:1379–1389. PMID: 29061270.
9. Becquemin JP, Pillet JC, Lescalie F, Sapoval M, Goueffic Y, Lermusiaux P, et al. A randomized controlled trial of endovascular aneurysm repair versus open surgery for abdominal aortic aneurysms in low- to moderate-risk patients. J Vasc Surg. 2011; 53:1167–1173. PMID: 21276681.
10. De Bruin JL, Baas AF, Buth J, Prinssen M, Verhoeven EL, Cuypers PW, et al. Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. N Engl J Med. 2010; 362:1881–1889. PMID: 20484396.
11. Greenhalgh RM, Brown LC, Powell JT, Thompson SG, Epstein D. United Kingdom EVAR Trial Investigators. Endovascular repair of aortic aneurysm in patients physically ineligible for open repair. N Engl J Med. 2010; 362:1872–1880. PMID: 20382982.
12. Lederle FA, Freischlag JA, Kyriakides TC, Matsumura JS, Padberg FT Jr, Kohler TR, et al. Long-term comparison of endovascular and open repair of abdominal aortic aneurysm. N Engl J Med. 2012; 367:1988–1997. PMID: 23171095.
13. United Kingdom EVAR Trial Investigators. Greenhalgh RM, Brown LC, Powell JT, Thompson SG, Epstein D, et al. Endovascular versus open repair of abdominal aortic aneurysm. N Engl J Med. 2010; 362:1863–1871. PMID: 20382983.
14. Trooboff SW, Wanken ZJ, Gladders B, Columbo JA, Lurie JD, Goodney PP. longitudinal spending on endovascular and open abdominal aortic aneurysm repair. Circ Cardiovasc Qual Outcomes. 2020; 13:e006249. PMID: 32375504.
15. Columbo JA, Goodney PP, Gladders BH, Tsougranis G, Wanken ZJ, Trooboff SW, et al. Medicare costs for endovascular abdominal aortic aneurysm treatment in the Vascular Quality Initiative. J Vasc Surg. 2021; 73:1056–1061. PMID: 32682064.
16. Byun E, Kwon TW, Kim H, Cho YP, Han Y, Ko GY, et al. Quality-adjusted life year comparison at medium term follow-up of endovascular versus open surgical repair for abdominal aortic aneurysm in young patients. PLoS One. 2021; 16:e0260690. PMID: 34855851.
17. Lederle FA, Stroupe KT, Kyriakides TC, Ge L, Freischlag JA. Open vs Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Long-term cost-effectiveness in the veterans affairs open vs endovascular repair study of aortic abdominal aneurysm: a randomized clinical trial. JAMA Surg. 2016; 151:1139–1144. PMID: 27627802.
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