Perinatology.  2023 Jun;34(2):64-68. 10.14734/PN.2023.34.2.64.

Neonatal Treatment and Outcomes of Patients with Trisomy 18 in the Neonatal Intensive Care Unit: A Single Center Study

• Shin BS
• Ko JM
• Shin SH

• KMID: 2544096
• DOI: http://doi.org/10.14734/PN.2023.34.2.64

Abstract

Objective
Recent studies have shown that aggressive surgical intervention has extended the life span of patients with trisomy 18 syndrome. This study summarized patients with trisomy 18 syndrome in a single center neonatal intensive care unit (NICU).
Methods
This retrospective study reviewed the medical records of nine patients who diagnosed as trisomy 18 syndrome who were born in our hospital or were transferred in NICU. Data of clinical infor mation and results of chromosome test were collected.
Results
Of nine patients we investigated, seven patients were alive and kept following up. Five pa tients underwent heart surgery, three patients underwent surgical correction of esophageal atresia. Three patients received tracheotomy due to airway problems. Most of patients except one had mode rate to severe developmental delay. Three patients were partial trisomy 18, and their clinical features were a little better than those of full trisomy patient.
Conclusion
Surgical intervention for patients with trisomy 18 syndrome can prolong the life of the patient, but does not guarantee the quality of life. Therefore, the family of patients should be involved in determining the treatment direction.

Keyword

Trisomy 18 syndrome; Prognosis; Surgical procedures; Intensive care units