Korean J Vet Res.
2023 Jun;63(2):e15. 10.14405/kjvr.20230019.
Experimental infection of a porcine kidney cell line with hepatitis A virus
- Affiliations
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- 1Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
- 2Konkuk University Zoonotic Diseases Research Center, Konkuk University, Seoul 05029, Korea
- 3KU Center for Animal Blood Medical Science, Konkuk University, Seoul 05029, Korea
- KMID: 2543762
- DOI: http://doi.org/10.14405/kjvr.20230019
Abstract
- The hepatitis A virus (HAV) induces severe acute liver injury and is adapted to human and monkey cell lines but not other cells. In this study, the HAV was inoculated into porcine kidney (PK-15) cells to determine its infectivity in porcine cells. The growth pattern of the HAV in PK-15 cells was compared with its growth pattern in fetal rhesus kidney (FRhK-4) cells. The growth of HAV was less efficient in PK-15 cells. In conclusion, HAV replication was verified in PK-15 cells for the first time. Further investigations will be needed to identify the HAV-restrictive mechanisms in PK-15 cells.
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