Korean J Dermatol.
2023 May;61(4):239-243.
A Case of Merkel Cell Polyomavirus-Negative Merkel Cell Carcinoma Concurrent with Squamous Cell Carcinoma
- Affiliations
-
- 1Departments of Dermatology, Inha University School of Medicine, Incheon, Korea
- 2Departments of Pathology, Inha University School of Medicine, Incheon, Korea
Abstract
- Merkel cell carcinoma (MCC), a rare cutaneous neuroendocrine carcinoma, is most common in sun-exposed areas of aged individuals. Merkel cell polyomavirus (MCPyV) is one causative agent of MCC. Cases of MCC concurrent with other skin tumors, especially squamous cell carcinoma, are rarely reported. Immunohistochemical staining is performed using antibodies to the MCPyV large-T antigen (CM2B4) only in select cases. To date, no cases of MCPyV have been reported in Korea. Here we report a case of MCC concurrent with squamous cell carcinoma in an aged man and discuss the pathogenesis of the case through CM2B4 staining.
