Clin Exp Reprod Med.  2023 Jun;50(2):69-77. 10.5653/cerm.2023.05925.

Female reproduction and abnormal uterine bleeding after COVID-19 vaccination

• Paik H
• Kim SK

• KMID: 2542565
• DOI: http://doi.org/10.5653/cerm.2023.05925

Abstract

Coronavirus disease 2019 (COVID-19) vaccines have been widely administered throughout the global community to minimize the morbidity and mortality caused by the COVID-19 pandemic. Although generally well-tolerated, these vaccines have generated some unwanted consequences, including thrombosis and menstrual irregularities. The effect of vaccination on female reproductive function has also been questioned. The aim of this review is to give readers a clear understanding of the effects of COVID-19 vaccines on thrombosis, reproductive function, and menstrual irregularities by systemically analyzing the available literature. The available evidence suggests that COVID-19 vaccines have a minimal impact on ovarian reserve. Furthermore, in vitro fertilization outcomes after COVID-19 vaccination remain unimpaired compared to those who did not receive the vaccines. Current evidence supports a certain degree of impact of COVID-19 vaccines on the menstrual cycle, with the most frequent alteration being menstrual irregularity, followed by menorrhagia. These changes are generally well-tolerated and transient, lasting less than 2 months. This review, by providing information with up-to-date references on this issue, may enhance readers’ understanding of the impact of COVID-19 vaccines on female reproductive function and the menstrual cycle.

Keyword

COVID-19; Fertilization; Menstruation; Menstruation disturbances; Vaccination