Korean J Otorhinolaryngol-Head Neck Surg.
2023 May;66(5):295-301. 10.3342/kjorl-hns.2022.01102.
The Mechanisms and Overcoming Strategies of the Radioresistance in Head and Neck Cancer
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- 1Department of Otolaryngology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
- KMID: 2542402
- DOI: http://doi.org/10.3342/kjorl-hns.2022.01102
Abstract
- Radiotherapy plays an important role in the treatment of most of solid tumors including head and neck squamous cell carcinoma (HNSCC). Radioresistance can lead to locoregional recurrence and distant metastases. Despite significant progress in research of radioresistance, its prediction and overcoming strategies remain challenging. This review describes the potential biomarkers correlated to the radioresistance and complex signal pathway in mechanism of radioresistance focusing on the PI3K and EphA3 pathway.
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