J Korean Neurol Assoc.  2023 May;41(2):145-148. 10.17340/jkna.2023.2.8.

A Case of de novo MPO-associated Central Nervous System Vasculitis Following Heterogeneous mRNA1273 COVID-19 Booster Vaccination

• Jeong YS
• Bang SJ
• Kim GY
• Jeon JH
• Oh GR
• Chung CH
• Park H

• KMID: 2542152
• DOI: http://doi.org/10.17340/jkna.2023.2.8

Abstract

The coronavirus disease-19 (COVID-19) pandemic leaded to inevitable expeditious vaccine rollout without sufficient safety profile. Especially, severe acute respiratory syndrome coronavirus 2 infection has known to induce overreacted immune responses such as releasing of proteinase-3 and myeloperoxidase (MPO) by neutrophil. This overreacted immune response leads to the concern of the development of autoimmune diseases after COVID-19 vaccination. We report the case of de novo MPO-associated systemic vasculitis involving central nervous system following heterogeneous mRNA1273 COVID-19 booster vaccination.

Keyword

Coronavirus; Antibodies; antineutrophil cytoplasmic; Vasculitis