J Korean Neurol Assoc.  2023 May;41(2):121-127. 10.17340/jkna.2023.2.3.

Decision-making Approach in Late-onset Bilateral Semantic Variant Primary Progressive Aphasia with Coexisting Asymmetric Regional Amyloid Deposition

Affiliations
  • 1Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

Abstract

Semantic variant primary progressive aphasia (svPPA), a well-known subtype of the frontotemporal dementia often shows peculiar clinical features and structural neuroimage findings. To strengthen the accuracy of a clinical diagnosis, amyloid positron emission tomography-computed tomography (PET-CT) might be helpful. However, in patients with late-onset svPPA, an admixture of the various neuropathology would interfere with diagnostic approach. Herein, we report a case of late-onset bilateral svPPA showing a regional amyloid deposition on PET-CT scan.

Keyword

Semantics; Frontotemporal dementia; Amyloid
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