J Korean Neurosurg Soc.  2023 May;66(3):281-288. 10.3340/jkns.2023.0044.

Permanent Surgical Treatment for Posthemorrhagic Hydrocephalus in Preterm Infants

Affiliations
  • 1Department of Pediatric Neurosurgery, Takatsuki General Hospital, Osaka, Japan

Abstract

While the standard management for posthemorrhagic hydrocephalus (PHH) has not been determined, many patients initially receive temporary treatment such as a ventricular drainage, a ventricular reservoir, or a ventriculosubgaleal shunt. Subsequently, approximately 15% of patients with PHH will require permanent cerebrospinal fluid diversion. Shunt placement is most commonly performed for PHH as permanent treatment. However, shunting still has high complication rates. Since the development of the neuroendoscopic technique has progressed, and indication has been expanded, endoscopic third ventriculostomy with or without choroid plexus cauterization has performed more frequently in recent years in patients with PHH. In this paper, the permanent treatment for PHH will be reviewed based on the latest evidence.

Keyword

Preterm infants; Intraventricular hemorrhage; Ventriculoperitoneal shunt; Endoscopic third ventriculostomy; Posthemorrhagic hydrocephalus

Figure

  • Fig. 1. Case presentation. A : Ultrasonography at the age of 1 day (left) and 28 days (right) demonstrating bilateral intraventricular hemorrhage developing to ventricular dilatation. B : T2-weighted magnetic resonance images at the age of 4 months before shunt operation showing enlargement of the ventricle. C : Lateral view of X-ray after shunt operation with a programmable valve.

  • Fig. 2. Strategy for the permanent treatment for posthemorrhagic hydrocephalus. CSF : cerebrospinal fluid, VP : ventriculo-peritoneal, ETV : endoscopic third ventriculostomy, CPC : choroid plexus cauterization.


Reference

References

1. Baird LC, Mazzola CA, Auguste KI, Klimo P Jr, Flannery AM; Pediatric Hydrocephalus Systematic Review and Evidence-Based Guidelines Task Force. Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 5: effect of valve type on cerebrospinal fluid shunt efficacy. J Neurosurg Pediatr. 14 Suppl 1:35–43. 2014.
Article
2. Balthasar AJ, Kort H, Cornips EM, Beuls EA, Weber JW, Vles JS. Analysis of the success and failure of endoscopic third ventriculostomy in infants less than 1 year of age. Childs Nerv Syst. 23:151–155. 2007.
Article
3. Beez T, Sarikaya-Seiwert S, Bellstädt L, Mühmer M, Steiger HJ. Role of ventriculoperitoneal shunt valve design in the treatment of pediatric hydrocephalus--a single center study of valve performance in the clinical setting. Childs Nerv Syst. 30:293–297. 2014.
Article
4. Benzel EC, Reeves JD, Kesterson L, Hadden TA. Slit ventricle syndrome in children: clinical presentation and treatment. Acta Neurochir (Wien). 117:7–14. 1992.
Article
5. Bir SC, Konar S, Maiti TK, Kalakoti P, Bollam P, Nanda A. Outcome of ventriculoperitoneal shunt and predictors of shunt revision in infants with posthemorrhagic hydrocephalus. Childs Nerv Syst. 32:1405–1414. 2016.
Article
6. Bock HC, Feldmann J, Ludwig HC. Early surgical management and long-term surgical outcome for intraventricular hemorrhage-related posthemorrhagic hydrocephalus in shunt-treated premature infants. J Neurosurg Pediatr. 22:61–67. 2018.
Article
7. Chamiraju P, Bhatia S, Sandberg DI, Ragheb J. Endoscopic third ventriculostomy and choroid plexus cauterization in posthemorrhagic hydrocephalus of prematurity. J Neurosurg Pediatr. 13:433–439. 2014.
Article
8. Cherian S, Whitelaw A, Thoresen M, Love S. The pathogenesis of neonatal post-hemorrhagic hydrocephalus. Brain Pathol. 14:305–311. 2004.
Article
9. Chittiboina P, Pasieka H, Sonig A, Bollam P, Notarianni C, Willis BK, et al. Posthemorrhagic hydrocephalus and shunts: what are the predictors of multiple revision surgeries? J Neurosurg Pediatr. 11:37–42. 2013.
Article
10. Cinalli G, Spennato P, Savarese L, Ruggiero C, Aliberti F, Cuomo L, et al. Endoscopic aqueductoplasty and placement of a stent in the cerebral aqueduct in the management of isolated fourth ventricle in children. J Neurosurg. 104(1 Suppl):21–27. 2006.
Article
11. Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, BenaventeFernández I, van Straaten HLM, et al. Randomized controlled early versus late ventricular intervention study in posthemorrhagic ventricular dilatation: outcome at 2 years. J Pediatr. 226:28–35.e3. 2020.
12. Drake JM; Canadian Pediatric Neurosurgery Study Group. Endoscopic third ventriculostomy in pediatric patients: the Canadian experience. Neurosurgery. 60:881–886. 2007.
13. du Plessis AJ. Cerebrovascular injury in premature infants: current understanding and challenges for future prevention. Clin Perinatol. 35:609–641. v, 2008.
Article
14. Elgamal EA, El-Dawlatly AA, Murshid WR, El-Watidy SM, Jamjoom ZA. Endoscopic third ventriculostomy for hydrocephalus in children younger than 1 year of age. Childs Nerv Syst. 27:111–116. 2011.
Article
15. Fulkerson DH, Vachhrajani S, Bohnstedt BN, Patel NB, Patel AJ, Fox BD, et al. Analysis of the risk of shunt failure or infection related to cerebrospinal fluid cell count, protein level, and glucose levels in lowbirth-weight premature infants with posthemorrhagic hydrocephalus. J Neurosurg Pediatr. 7:147–151. 2011.
Article
16. Heep A, Engelskirchen R, Holschneider A, Groneck P. Primary intervention for posthemorrhagic hydrocephalus in very low birthweight infants by ventriculostomy. Childs Nerv Syst. 17:47–51. 2001.
Article
17. Kestle JR, Holubkov R, Douglas Cochrane D, Kulkarni AV, Limbrick DD Jr, Luerssen TG, et al. A new Hydrocephalus Clinical Research Network protocol to reduce cerebrospinal fluid shunt infection. J Neurosurg Pediatr. 17:391–396. 2016.
Article
18. Köksal V, Öktem S. Ventriculosubgaleal shunt procedure and its longterm outcomes in premature infants with post-hemorrhagic hydrocephalus. Childs Nerv Syst. 26:1505–1515. 2010.
Article
19. Kulkarni AV, Riva-Cambrin J, Holubkov R, Browd SR, Cochrane DD, Drake JM, et al. Endoscopic third ventriculostomy in children: prospective, multicenter results from the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr. 18:423–429. 2016.
Article
20. Limbrick DD Jr, de Vries LS. New insights into the management of posthemorrhagic hydrocephalus. Semin Perinatol. 46:151597. 2022.
Article
21. Lu VM, Wang S, Niazi TN, Ragheb J. Impact of intraventricular hemorrhage symmetry on endoscopic third ventriculostomy with choroid plexus cauterization for posthemorrhagic hydrocephalus: an institutional experience of 50 cases. J Neurosurg Pediatr. 31:245–251. 2022.
Article
22. Mazzola CA, Choudhri AF, Auguste KI, Limbrick DD Jr, Rogido M, Mitchell L, et al. Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: management of posthemorrhagic hydrocephalus in premature infants. J Neurosurg Pediatr 14 Suppl. 1:8–23. 2014.
Article
23. McGirt MJ, Leveque JC, Wellons JC 3rd, Villavicencio AT, Hopkins JS, Fuchs HE, et al. Cerebrospinal fluid shunt survival and etiology of failures: a seven-year institutional experience. Pediatr Neurosurg. 36:248–255. 2002.
Article
24. Notarianni C, Vannemreddy P, Caldito G, Bollam P, Wylen E, Willis B, et al. Congenital hydrocephalus and ventriculoperitoneal shunts: influence of etiology and programmable shunts on revisions. J Neurosurg Pediatr. 4:547–552. 2009.
Article
25. Oi S, Matsumoto S. Pathophysiology of aqueductal obstruction in isolated IV ventricle after shunting. Childs Nerv Syst. 2:282–286. 1986.
Article
26. Park YS, Kotani Y, Kim TK, Yokota H, Sugimoto T, Nakagawa I, et al. Efficacy and safety of intraventricular fibrinolytic therapy for postintraventricular hemorrhagic hydrocephalus in extreme low birth weight infants: a preliminary clinical study. Childs Nerv Syst. 37:69–79. 2021.
Article
27. Parker SL, Attenello FJ, Sciubba DM, Garces-Ambrossi GL, Ahn E, Weingart J, et al. Comparison of shunt infection incidence in high-risk subgroups receiving antibiotic-impregnated versus standard shunts. Childs Nerv Syst. 25:77–83. discussion 85. 2009.
Article
28. Pomeraniec IJ, Ksendzovsky A, Ellis S, Roberts SE, Jane JA Jr. Frequency and long-term follow-up of trapped fourth ventricle following neonatal posthemorrhagic hydrocephalus. J Neurosurg Pediatr. 17:552–557. 2016.
Article
29. Reinprecht A, Dietrich W, Berger A, Bavinzski G, Weninger M, Czech T. Posthemorrhagic hydrocephalus in preterm infants: long-term followup and shunt-related complications. Childs Nerv Syst. 17:663–669. 2001.
Article
30. Robinson S. Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts. J Neurosurg Pediatr. 9:242–258. 2012.
Article
31. Valdez Sandoval P, Hernández Rosales P, Quiñones Hernández DG, Chavana Naranjo EA, García Navarro V. Intraventricular hemorrhage and posthemorrhagic hydrocephalus in preterm infants: diagnosis, classification, and treatment options. Childs Nerv Syst. 35:917–927. 2019.
Article
32. Sciubba DM, Noggle JC, Carson BS, Jallo GI. Antibiotic-impregnated shunt catheters for the treatment of infantile hydrocephalus. Pediatr Neurosurg. 44:91–96. 2008.
Article
33. Schulz M, Bührer C, Pohl-Schickinger A, Haberl H, Thomale UW. Neuroendoscopic lavage for the treatment of intraventricular hemorrhage and hydrocephalus in neonates. J Neurosurg Pediatr. 13:626–635. 2014.
Article
34. Stone SS, Warf BC. Combined endoscopic third ventriculostomy and choroid plexus cauterization as primary treatment for infant hydrocephalus: a prospective North American series. J Neurosurg Pediatr. 14:439–446. 2014.
Article
35. Tuli S, Drake J, Lawless J, Wigg M, Lamberti-Pasculli M. Risk factors for repeated cerebrospinal shunt failures in pediatric patients with hydrocephalus. J Neurosurg. 92:31–38. 2000.
Article
36. Wang JY, Amin AG, Jallo GI, Ahn ES. Ventricular reservoir versus ventriculosubgaleal shunt for posthemorrhagic hydrocephalus in preterm infants: infection risks and ventriculoperitoneal shunt rate. J Neurosurg Pediatr. 14:447–454. 2014.
Article
37. Wang JY, Jackson EM, Jallo GI, Ahn ES. Shunt revision requirements after posthemorrhagic hydrocephalus of prematurity: insight into the time course of shunt dependency. Childs Nerv Syst. 31:2123–2130. 2015.
Article
38. Warf BC. Comparison of endoscopic third ventriculostomy alone and combined with choroid plexus cauterization in infants younger than 1 year of age: a prospective study in 550 African children. J Neurosurg. 103(6 Suppl):475–481. 2005.
Article
39. Warf BC, Campbell JW, Riddle E. Initial experience with combined endoscopic third ventriculostomy and choroid plexus cauterization for post-hemorrhagic hydrocephalus of prematurity: the importance of prepontine cistern status and the predictive value of FIESTA MRI imaging. Childs Nerv Syst. 27:1063–1071. 2011.
Article
40. Whitelaw A, Aquilina K. Management of posthaemorrhagic ventricular dilatation. Arch Dis Child Fetal Neonatal Ed. 97:F229–3. 2012.
Article
41. Willis B, Javalkar V, Vannemreddy P, Caldito G, Matsuyama J, Guthikonda B, et al. Ventricular reservoirs and ventriculoperitoneal shunts for premature infants with posthemorrhagic hydrocephalus: an institutional experience. J Neurosurg Pediatr. 3:94–100. 2009.
Article
Full Text Links
  • JKNS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr