J Dig Cancer Res.  2023 Apr;11(1):45-48. 10.52927/jdcr.2023.11.1.45.

Mechanism and Treatment of Chemotherapy-induced Peripheral Neuropathy

• Jang DK

• KMID: 2541628
• DOI: http://doi.org/10.52927/jdcr.2023.11.1.45

Abstract

One of the most common side effects of chemotherapeutic agents is chemotherapy-induced peripheral neuropathy (CIPN). The occurrence of CIPN is increasing as the survival rate of patients with cancer improves and the cumulative dose or duration of neurotoxic drugs increases. Approximately 30–40% of patients receiving neurologically toxic drugs experience CIPN, which eventually increases the burden of medical expenses. However, preventive measures against CIPN have not yet been established. Clinical trials have tested various drugs for the management of neuropathic pain, but only duloxetine has shown any significant effect. Further studies should evaluate nonpharmaceutical treatments, such as exercise.

Keyword

Chemotherapy; Side effect; Neuropathy