Ann Dermatol.
2023 Apr;35(2):91-99. 10.5021/ad.22.175.
The Tumor Immune Microenvironment in Cutaneous Squamous Cell Carcinoma Arising in Organ Transplant Recipients
- Affiliations
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- 1Department of Dermatology, The University of Sydney at Royal Prince Alfred Hospital, Sydney, Australia
- 2Centenary Institute, The University of Sydney, Sydney, Australia
- 3Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW Health Pathology, Sydney, Australia
- 4Melanoma Institute Australia, Sydney, Australia
- KMID: 2541111
- DOI: http://doi.org/10.5021/ad.22.175
Abstract
- Cutaneous squamous cell carcinoma (cSCC) is the most common malignancy in immunesuppressed organ transplant recipients (OTRs). Whilst rates of other malignancies (both cutaneous and non-cutaneous) are elevated in this population, the increase is far less striking. This suggests that cSCC must be a highly immunogenic tumor. The tumor immune microenvironment is altered in cSCC from OTRs. It has reduced anti-tumor properties and instead provides an environment that facilitates tumor growth and survival. Understanding the composition and function of the tumor immune microenvironment in cSCC from OTRs is useful for prognostication and therapeutic decisions.
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