Clin Endosc.  2023 Mar;56(2):258-260. 10.5946/ce.2022.203.

Chronic non-healing gastric ulcer in a patient with poorly controlled diabetes mellitus

Affiliations
  • 1Gastroenterology and Hepatology Unit, Department of Internal Medicine, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam
  • 2Department of Pathology, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam
  • 3Department of Radiology, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam
  • 4Division of Infectious Disease, Department of Medicine, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam
  • 5Department of Medicine, PMMPHAMB Hospital, Tutong, Brunei Darussalam


Figure

  • Fig. 1. Axial (A) and coronal (B) contrast-enhanced computed tomography images show diffuse thickening of the stomach wall, mainly of the submucosal layer along the lesser curvature (arrowheads), with reactive peri-gastric adenopathy (arrows).

  • Fig. 2. Endoscopic findings. An incisura showing edematous mucosa with a deep penetrating ulcer with narrowing of the gastric lumen (A), and mild erosions in the otherwise normal antrum (B).

  • Fig. 3. (A) Hematoxylin and eosin stain of gastric biopsy showing fungal hyphae amongst necrotic tissues (×200). (B) Grocott methenamine silver stain showing the fungal hyphae more clearly (×200).


Reference

1. Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005; 41:634–653.
2. Patel A, Kaur H, Xess I, et al. A multicentre observational study on the epidemiology, risk factors, management and outcomes of mucormycosis in India. Clin Microbiol Infect. 22020; 26:944–950.
3. Didehdar M, Chegini Z, Moradabadi A, et al. Gastrointestinal mucormycosis: a periodic systematic review of case reports from 2015 to 2021. Microb Pathog. 2022; 163:105388.
4. Sharma D. Successful management of emphysematous gastritis with invasive gastric mucormycosis. BMJ Case Rep. 2020; 13:e231297.
5. Mittal T, Pulle MV, Dey A, et al. Gastric mucormycosis presenting as gastrocolic fistula: a rare entity. Indian J Surg. 2016; 78:511–512.
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