Korean J Vet Res.
2022 Dec;62(4):e27. 10.14405/kjvr.20220027.
Neuronal ceroid lipofuscinosis in a Border Collie: a case report
- Affiliations
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- 1Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea
- 2Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea
- KMID: 2540206
- DOI: http://doi.org/10.14405/kjvr.20220027
Abstract
- A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.
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