J Korean Acad Pediatr Dent.  2023 Feb;50(1):1-12. 10.5933/JKAPD.2023.50.1.1.

Trends in Saliva Research and Biomedical Clinical Applications

• Park S
• Lee E
• Shin J
• Jeong T

• KMID: 2539892
• DOI: http://doi.org/10.5933/JKAPD.2023.50.1.1

Abstract

Function of salivary gland and saliva composition can be an indicator of individual’s health status. Recently, saliva has been thought to have a high potential for usage in the biomedical field to diagnose, evaluate, and prevent systemic health due to the technological advances in analyzing and detecting small elements such as immunological and metabolic products, viruses, microorganisms, hormones in saliva. As a diagnostic specimen, saliva has some useful advantages compared to serum. Because of simple non-invasive method, saliva sampling is quite comfort for the patient, and it doesn’t require specialists to collect samples. The possibility of infection during the collection process is also low. For this reason, proteins, genetic materials, and various biomarkers in saliva are actively being utilized on studying stress, microbiomics, genetics, and epigenetics. For the research on collecting big data related to systemic health, the needs on biobank has been focused. Regeneration of salivary gland based on tissue engineering has been also on advancement. However, there are still many issues to be solved, such as the standardization of sample collection, storage, and usage. This review focuses on the recent trends in the field of saliva research and highlight the future perspectives in biomedical and other applications.

Keyword

Saliva; Stress; Genetics; Microbiome; Biobank; Regeneration