Clin Mol Hepatol.
2023 Feb;29(Suppl):S302-S318. 10.3350/cmh.2022.0329.
Non-alcoholic fatty liver disease: the pathologist’s perspective
- Affiliations
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- 1Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore
- 2Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
- 3Pathology and Laboratory Department, Cardinal Santos Medical Center, San Juan, Philippines
- 4Department of Pathology and State Key Laboratory of Liver Research (HKU), The University of Hong Kong, Hong Kong, China
- 5Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- 6Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2539810
- DOI: http://doi.org/10.3350/cmh.2022.0329
Abstract
- Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases characterized by fatty accumulation in hepatocytes, ranging from steatosis, non-alcoholic steatohepatitis, to cirrhosis. While histopathological evaluation of liver biopsies plays a central role in the diagnosis of NAFLD, limitations such as the problem of interobserver variability still exist and active research is underway to improve the diagnostic utility of liver biopsies. In this article, we provide a comprehensive overview of the histopathological features of NAFLD, the current grading and staging systems, and discuss the present and future roles of liver biopsies in the diagnosis and prognostication of NAFLD.
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