Clin Mol Hepatol.  2023 Feb;29(Suppl):S244-S260. 10.3350/cmh.2022.0364.

Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease

• Semmler G
• Datz C
• Trauner M

• KMID: 2539805
• DOI: http://doi.org/10.3350/cmh.2022.0364

Abstract

Nutrition and dietary interventions are a central component in the pathophysiology, but also a cornerstone in the management of patients with non-alcoholic fatty liver disease (NAFLD). Summarizing our rapidly advancing understanding of how our diet influences our metabolism and focusing on specific effects on the liver, we provide a comprehensive overview of dietary concepts to counteract the increasing burden of NAFLD. Specifically, we emphasize the importance of dietary calorie restriction independently of the macronutrient composition together with adherence to a Mediterranean diet low in added fructose and processed meat that seems to exert favorable effects beyond calorie restriction. Also, we discuss intermittent fasting as a type of diet specifically tailored to decrease liver fat content and increase ketogenesis, awaiting future study results in NAFLD. Finally, personalized dietary recommendations could be powerful tools to increase the effectiveness of dietary interventions in patients with NAFLD considering the genetic background and the microbiome, among others.

Keyword

NAFLD; Mediterranean diet; Intermittent fasting; Calorie restricted diet; Precision medicine