Child Kidney Dis.  2022 Dec;26(2):91-96. 10.3339/ckd.22.033.

Newly diagnosed pediatric immunoglobulin A nephropathy after vaccination against SARS-CoV-2: a case report

• Kim DY
• Yim HE
• Son MH
• Yoo KH

• KMID: 2538740
• DOI: http://doi.org/10.3339/ckd.22.033

Abstract

The messenger RNA-based vaccine for the coronavirus disease 2019 (COVID-19) may induce glomerulonephritis, including immunoglobulin A nephropathy (IgAN). New-onset IgAN triggered by vaccination against COVID-19 has been reported rarely, especially in children. Herein, we report a pediatric case of newly diagnosed IgAN after administration of the Pfizer vaccine for COVID-19. A 12-year-old girl was referred to our hospital for evaluation of gross hematuria after inoculation with the second dose of Pfizer’s COVID-19 vaccine; she had no adverse effects after the first dose. At the time of admission, she showed heavy proteinuria and persistent hematuria. Kidney biopsy revealed an IgAN, and she was treated with an oral steroid and an angiotensin-converting enzyme inhibitor. Four months after discharge, the proteinuria and hematuria resolved completely.

Keyword

BNT162 vaccine; Case reports; Glomerulonephritis; IGA; SARS-CoV-2

Figure

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  Fig. 1. Microscopic findings from the kidney biopsy. (A) Mesangial cell proliferation (black arrows). (B) Interstitial fibrosis (black arrow). (C) Immunoglobulin A deposits. (D) Electron dense deposits (white arrows) in the mesangial area (A and B: hematoxylin and eosin stain, ×40 and ×20; C: immunofluorescence staining, ×20; D: electron microscopy, ×6,000).

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  Fig. 2. Clinical course of our patient. The quantity of urine RBCs is scored according to five stages (0: 1–4 RBCs/HPF; 1: 5–9 RBCs/HPF; 2: 10–29 RBCs/HPF; 3: 30–60 RBCs/HPF; 4: >60 RBCs/HPF). RBCs, red blood cells; HPF, high power field; Cr, creatinine; PCR, protein-to-creatinine ratio; mRNA, messenger RNA; COVID-19, coronavirus disease of 2019.

Reference

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