Maxillofac Plast Reconstr Surg.  2022;44(1):5. 10.1186/s40902-022-00334-w.

4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing

• Kim SG

• KMID: 2538655
• DOI: http://doi.org/10.1186/s40902-022-00334-w

Abstract

4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administration increases VEGF, TGF-β1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound.