Lab Anim Res.
2022 Dec;38(4):287-293. 10.1186/s42826-022-00140-5.
Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests: a small scale study
- Affiliations
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- 1Section for Experimental Biomedicine, Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.
- 2Environmental Chemistry Department, Norwegian Institute for Air Research, Ås, Norway
- 3Division of Work Physiology, National Institute of Occupational Health, Oslo, Norway.
- 4Section for Animal Welfare, Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.
- 5Section for Stationary Clinics, Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.
- 6Physiology Unit, Department of Preclinical Sciences and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ås, Norway.
- KMID: 2537631
- DOI: http://doi.org/10.1186/s42826-022-00140-5
Abstract
- Background
All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J, and gained knowledge on their performance in three different behavioral tests; open field (OF) test, Barnes maze (BM) test and a restraint stress test.
Results
We found that the young males of the C57BL/6J strain spent more time moving in the OF. In the BM, the hybrid covered less ground before reaching the goal box during the first three sessions, than the C57BL/6J. The hybrid left more fecal pellets than C57BL/6J both in OF and BM. During the stress test, the C57BL/6J had a lower corticosterone response than the hybrid.
Conclusions
Our findings indicate that the C57BL/6J has a presumably higher locomotor activity and/or explorative behavior than the hybrid, while the hybrid appeared more sensitive to stress.
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